Isoflurane Fahrenheit Dosage/Direction for Use

Premedication: Drugs used for premedication should be selected for the individual patient, bearing in mind the respiratory depressant effect of lsoflurane. The use of anticholinergic drugs is a matter of choice.
Induction: lsoflurane with oxygen or with an oxygen/nitrous oxide may be used for induction, but more usually a short-acting barbiturate or other intravenous induction agent is administered followed by inhalation of the lsoflurane mixture.
It is recommended that induction with lsoflurane be initiated at a concentration of 0.5%. Concentrations of 1.5 to 3.0% usually produce surgical anesthesia in 7 to 10 minutes.
Maintenance: Surgical levels of anesthesia may be maintained with 1.0 - 2.5% lsoflurane in oxygen/nitrous oxide mixtures. An additional 0.5 - 1.0% lsoflurane may be required when given with oxygen alone.
Arterial pressure levels during maintenance tend to be inversely related to alveolar lsoflurane concentrations in the absence of other complicating factors. Excessive falls in blood pressure may be due to depth of anesthesia and in these circumstances, should be corrected by reducing the inspired lsoflurane concentration.
Recovery: The inspired concentration of Isoflurane may be reduced to 0.5% near the end of surgery or may be reduced to zero at the beginning of the skin closure.
Administration Equipment: It is recommended that Isoflurane should be vaporized using a flow-through vaporizer specifically calibrated for the agent, though non-calibrated vaporisers may be used, particularly with low flow or closed systems, in conjunction with equipment capable of monitoring inspired or expired concentrations.
lsoflurane does not contain stabilisers which, in other agents, may affect vaporizer output.
MAC (Minimum Alveolar Concentration) in man: (See table.)


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